The Gulf of Tadjoura‎ is a gulf or basin found in the Indian Ocean in the Horn of Africa. It lies at the entrance to the Red Sea, to the south of the straits of Bab-el-Mandeb. Most of its coastline belongs to Djibouti, apart from a short stretch on its southern shore, which is part of the territory of Somalia. There are also several small islands in the Gulf. At the entrance of the Gulf lies the largest island of Moucha, and Maskali, and at the bottom of the Gulf, separated by a narrow strip of land, are Ghoubbet-el-Kharab and Assal.

Due to its geographic distribution, the Gulf of Tadjoura’s wildlife is diverse with many fishing grounds, expansive coral reefs, and copious pearl oysters. Aside from the reefs, other marine habitats in the Gulf include salt pans, sea grass beds, and mangroves.

While there is some spectacular marine fauna and flora in the Gulf, some is near extinction or at serious environmental risk, including corals and Dugongs.

The coral reefs in the Gulf attract many divers and snorkellers and accounts for about 40% of the foreign tourists visiting Djibouti. The Gulf of Tadjoura is believed to be an ideal location for snorkelling with whale sharks and underwater photography. Tadjoura is also surrounded by the scenic green Goda Mountains that are around 1,700 metres high.